Publications | Dr. Holtzer Neuropsychology Cognition and Mobility Lab

Peer-Reviewed Publications

*Denotes current or former students as co-authors

Holtzer, R., Foley, F. W., Motl, R. W., Wagshul, M. E., Hernandez, M. E., Lipton, M. L., Picone, M. A., & Izzetoglu, M. (2024). Brain hemodynamic responses and fall prediction in older adults with multiple sclerosis. Mult Scler, 13524585241277400. https://doi.org/10.1177/13524585241277400

Holtzer, R., Choi, J., Motl, R. W., Foley, F. W., Wagshul, M. E., Hernandez, M. E., & Izzetoglu, M. (2024). Brain control of dual-task walking can be improved in aging and neurological disease. Geroscience. https://doi.org/10.1007/s11357-023-01054-3

Holtzer, R., Motl, R. W., Wagshul, M. E., Picone, M. A., Hernandez, M. E., Izzetoglu, M., Lipton, M. L., & Foley, F. W. (2024). Life space assessment and falls in older adults with multiple sclerosis. Mult Scler Relat Disord, 87, 105671. https://doi.org/10.1016/j.msard.2024.105671

Hernandez, M. E., Motl, R. W., Foley, F. W., Picone, M. A., Izzetoglu, M., Lipton, M. L., Wagshul, M., & Holtzer, R. (2024). Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults With Multiple Sclerosis. Neurorehabil Neural Repair, 15459683241273411. https://doi.org/10.1177/15459683241273411

*Luo, D. H., & Holtzer, R. (2024). Perceived physical and mental fatigability in older adults with and without multiple sclerosis. Mult Scler Relat Disord, 90, 105807. https://doi.org/10.1016/j.msard.2024.105807

Hsu, C. L., Holtzer, R., Tam, R. C., Al Keridy, W., & Liu-Ambrose, T. (2024). Physical reserve and its underpinning functional neural networks moderate the relationship between white matter hyperintensity and postural balance in older adults with subcortical ischemic vascular cognitive impairment. Sci Rep, 14(1), 17161. https://doi.org/10.1038/s41598-024-68050-1

Krasovsky, T., Holtzer, R., Jahjah, E., & Fruchter, E. (2024). Trait anxiety increases the attentional cost of walking in young adults: A cross-sectional study. J Affect Disord, 362, 716-722. https://doi.org/10.1016/j.jad.2024.07.027

*Cote, S. E., Wagshul, M., Foley, F. W., Picone, M. A., Lipton, M., Lee, J. S., & Holtzer, R. (2024). Frontal-striatal tract integrity and depression in older adults with and without multiple sclerosis. Neurol Sci. https://doi.org/10.1007/s10072-024-07316-y

Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M. E., & Holtzer, R. (2024). Initial validation of the university of Alabama Birmingham study of aging life-space assessment in older adults with multiple sclerosis. Mult Scler Relat Disord, 82, 105354. https://doi.org/10.1016/j.msard.2023.105354

Ma, D., Izzetoglu, M., Holtzer, R., & Jiao, X. (2023). Deep Learning Based Walking Tasks Classification in Older Adults Using fNIRS. IEEE Trans Neural Syst Rehabil Eng, 31, 3437-3447. https://doi.org/10.1109/tnsre.2023.3306365

*Brundage, K., Holtzer, R. (2023). Presence and Persistence of Perceived Subjective Cognitive Complaints and Incident Mild Cognitive Impairments Among Community-Residing Older Adults. The American Journal Geriatric Psychiatry. doi: 10.1016/j.jagp.2023.07.001. Online ahead of print.

*Cote S.E., Wagshul, M.E., Foley, F.W., Lipton, M.L., Holtzer, R. (2023). Caudate Volume and Symptoms of Apathy in Older Adults with Multiple Sclerosis. Multiple Sclerosis Journal. doi: 10.1177/13524585231188096. Online ahead of print.

*Cohen, H.R., Holtzer, R. (2023). The Association Between Perceived Social Support and Cognition in Older Adults with and without Multiple Sclerosis. Multiple Sclerosis and Related Disorders. doi: 10.1016/j.msard.2023.104913. Online ahead of print.

*Ross, D., Wagshul, M.E.,Izzetoglu, M., Holtzer, R. (2023). Cortical Thickness Moderates Intraindividual Variability in Prefrontal Cortex Activation Patterns of Older Adults During Walking. Journal of the International Neuropsychological Society. doi: 10.1017/S1355617723000371. Online ahead of print.

*Jacobs, S., Izzetoglu, M., Holtzer, R. (2023). The Impact of Music Making on Neural Efficiency & Dual-Task Walking Performance in Healthy Older Adults. Aging Neuropsychology and Cognition. Mar 31:1-19. doi: 10.1080/13825585.2023.2195615. Online ahead of print

*Wasserman, J., Holtzer, R. (2023). Depressive Symptoms Are Associated With Decline Over Time in Verbal Fluency Performance in Female But Not Male Community-Residing Older Adults. Experimental Aging Research. Mar 29:1-16. doi: 10.1080/0361073X.2023.2195295. Online ahead of print

Holtzer, R., Choi, J., Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M., & Wagshul, M. E. (2023). Individual reserve in aging and neurological disease. Journal of neurology, 1–13. Advance online publication. https://doi.org/10.1007/s00415-023-11656-8

*Pace, B., Holtzer, R., & Wagshul, M. E. (2023). Gray matter volume and within-task verbal fluency performance among older adults. Brain and cognition, 166, 105960. https://doi.org/10.1016/j.bandc.2023.105960

*O'Brien, C., & Holtzer, R. (2023). Physical reserve: construct development and predictive utility. Aging clinical and experimental research, 10.1007/s40520-023-02371-5. Advance online publication. https://doi.org/10.1007/s40520-023-02371-5

Holtzer, R., Feldman, J. M., Jariwala, S. P., & Izzetoglu, M. (2023). Asthma history influences gait performance and associated prefrontal cortex activation patterns in older adults. Aging clinical and experimental research, 35(2), 407–411. https://doi.org/10.1007/s40520-022-02306-6

Wagshul, M.,, Foley, F.W., Chaudhary, K., Lipton, M.L., Robert Motl, R., Izzetoglu, M., Hernandez, M.E., Picone, M.A., & Holtzer, R., (2023). Differential Associations of Mobility with Fronto-Striatal Integrity and Lesion Load in Older Adults with and without Multiple Sclerosis. Neurorehabilitation and Neural Repair. Apr;37(4):205-217. doi: 10.1177/15459683231164787.

Holtzer, R., Zhu, X., Rosso, A. L., & Rosano, C. (2022). Cognitive reserve and risk of mobility impairment in older adults. Journal of the American Geriatrics Society, 10.1111/jgs.17979. Advance online publication. https://doi.org/10.1111/jgs.17979

Krasovsky, T., Madi, R., Fruchter, E., Jahjah, E., & Holtzer, R. (2022). Prefrontal Cortex Brain Activation During Texting and Walking: A Functional Near-Infrared Spectroscopy Feasibility Study. Motor control, 1–10. Advance online publication. https://doi.org/10.1123/mc.2022-0009

*Guharajan, D., & Holtzer, R. (2022). Association of Affect and Performance in Dual-Task Walking in Non-demented Older Adults. Journal of aging and health, 8982643221087836. Advance online publication. https://doi.org/10.1177/08982643221087836

Holtzer R. (2022). Volitional control of walking in aging. Aging, 14(6), 2440–2441. https://doi.org/10.18632/aging.203986

Maidan, I., Hacham, R., Galperin, I., Giladi, N., Holtzer, R., Hausdorff, J. M., & Mirelman, A. (2021). Neural Variability in the Prefrontal Cortex as a Reflection of Neural Flexibility and Stability in Patients With Parkinson Disease. Neurology. Advance online publication. https://doi.org/10.1212/WNL.0000000000013217

Holtzer, R., *Ross, D., O'Brien, C., Izzetoglu, M., & Wagshul, M. E. (2021). Cognitive Reserve Moderates the Efficiency of Prefrontal Cortex Activation Patterns of Gait in Older Adults. The Journals of Gerontology: Series A. Advance online publication. https://doi.org/10.1093/gerona/glab288

Verghese, J., Mahoney, J. R., Ayers, E., Ambrose, A., Wang, C., & Holtzer, R. (2021). Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial. Lancet Healthy Longev, 2(9), e571–e579. https://doi.org/10.1016/s2666-7568(21)00173-2

*Ross, D., Wagshul, M. E., Izzetoglu, M., & Holtzer, R. (2021). Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions. GeroScience, 43(4), 1959-1974. https://doi.org/10.1007/s11357-021-00379-1

*O'Brien, C., & Holtzer, R. (2021). Cognitive Reserve Moderates Associations Between Walking Performance Under Single and Dual-Task Conditions and Incident Mobility Impairment in Older Adults. The Journals of Gerontology: Series A, 76(10), e314-e320. https://doi.org/10.1093/gerona/glab178

*Kraut, R., & Holtzer, R. (2021). Recurrent but not single report of fear of falling predicts cognitive decline in community-residing older adults. Aging & mental health, 1–7. Advance online publication. https://doi.org/10.1080/13607863.2021.1916878

Bishnoi, A., Holtzer, R., & Hernandez, M. E. (2021). Brain Activation Changes While Walking in Adults with and without Neurological Disease: Systematic Review and Meta-Analysis of Functional Near-Infrared Spectroscopy Studies. Brain sciences, 11(3), 291. https://doi.org/10.3390/brainsci11030291

*Pakray, H., Seng, E., Izzetoglu, M., & Holtzer, R. (2021). The Effects of Perceived Pain in the Past Month on Prefrontal Cortex Activation Patterns Assessed During Cognitive and Motor Performances in Older Adults. Pain medicine, 22(2), 303–314. https://doi.org/10.1093/pm/pnaa404

*Holtzer, R., Ross, D., & Izzetoglu, M. (2020). Intraindividual variability in neural activity in the prefrontal cortex during active walking in older adults. Psychology and aging, 35(8), 1201–1214. https://doi.org/10.1037/pag0000583

Menant, J. C., Maidan, I., Alcock, L., Al-Yahya, E., Cerasa, A., Clark, D. J., de Bruin, E. D., Fraser, S., Gramigna, V., Hamacher, D., Herold, F., Holtzer, R., Izzetoglu, M., Lim, S., Pantall, A., Pelicioni, P., Peters, S., Rosso, A. L., St George, R., Stuart, S., … Mirelman, A. (2020). A consensus guide to using functional near-infrared spectroscopy in posture and gait research. Gait & posture, 82, 254–265. https://doi.org/10.1016/j.gaitpost.2020.09.012

*Jacobs, S., Mercuri, G., & Holtzer, R. (2021). Assessing within-task verbal fluency performance: the utility of individual time intervals in predicting incident mild cognitive impairment. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 28(5), 733-747. https://doi.org/10.1080/13825585.2020.1817306

*Mercuri, G., & Holtzer, R. (2021). Engagement in Cognitively Stimulating Activities Mediates the Relationship between Openness and Attention/Executive Functions, but Not Memory in Older Adults. Archives of Clinical Neuropsychology. 36(4), 485-497. https://doi.org/10.1093/arclin/acaa066

Holtzer, R., & Izzetoglu, M. (2020). Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults. Brain sciences, 10(7), 415. https://doi.org/10.3390/brainsci10070415

Izzetoglu, M., & Holtzer, R. (2020). Effects of Processing Methods on fNIRS Signals Assessed During Active Walking Tasks in Older Adults. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 28(3), 699–709. https://doi.org/10.1109/TNSRE.2020.2970407

*Lee, J., & Holtzer, R. (2021). Independent associations of apathy and depressive symptoms with perceived social support in healthy older adults. Aging & mental health, 25(10), 1796-1802. https://doi.org/10.1080/13607863.2020.1768217

*Holtzer, R., Jacobs, S., & Demetriou, E. (2020). Intraindividual variability in verbal fluency performance is moderated by and predictive of mild cognitive impairments. Neuropsychology, 34(1), 31–42. https://doi.org/10.1037/neu0000576

Udina, C., Avtzi, S., Durduran, T., Holtzer, R., Rosso, A. L., Castellano-Tejedor, C., Perez, L. M., Soto-Bagaria, L., & Inzitari, M. (2020). Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review. Frontiers in aging neuroscience, 11, 367. https://doi.org/10.3389/fnagi.2019.00367

Zhang, W. B., Aleksic, S., Gao, T., Weiss, E. F., Demetriou, E., Verghese, J., Holtzer, R., Barzilai, N., & Milman, S. (2020). Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults. Cells, 9(6), 1368. https://doi.org/10.3390/cells9061368

*Jacobs, S. & Holtzer, R. (2021). Predicting Change in Perceived Social Support in Late Life: The Role of Personality and Gender. Aging Ment Health. 25(1), 107-117. doi: 10.1080/13607863.2019.1671317.

Hoffnung, G., Portnoy, J.G., Altaras, C., Zemon, V., Holtzer, R., Picone, M.A., Foley, F.W. (2019). Motivation in Multiple Sclerosis Cognitive Fatigue: An Experimental Approach. J Clin Exp Neuropsychol. doi: 10.1080/13803395.2019.1626350.

Hernandez, M. E., O'Donnell, E., Chaparro, G., Holtzer, R., Izzetoglu, M., Sandroff, B. M., & Motl, R. W. (2019). Brain Activation Changes During Balance- and Attention-Demanding Tasks in Middle- and Older-Aged Adults With Multiple Sclerosis. Motor Control, 15, 1-20. doi: 10.1123/mc.2018-0044.

*Holtzer, R., Kraut, R., & Ye, K. (2019). The effect of fear of falling on prefrontal cortex activation and efficiency. GeroScience, 41:1, 89-100. doi: 10.1007/s11357-019-00056-4.

*Wagshul, M. E., Lucas, M., Izzetoglu, M., Ye, K., & Holtzer, R. (2019). Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults. NeuroImage, 1:189, 745-754. doi: 10.1016/j.neuroimage.2019.01.045.

George, C.J., Verghese, J., Izzetoglu, M., Wang, C., & Holtzer, R. (2019). The effect of polypharmacy on prefrontal cortex activation during single and dual-task walking in community dwelling older adults. Pharmacological Research, 139, 113-119. doi: 10.1016/j.phrs.2018.11.007.

*Lucas, M., Wagshul, M. E., Izzetoglu, M., & Holtzer, R. (2019). Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults. Journal of Gerontology Biological Sciences, 74:4, 435-441. doi: 10.1093/gerona/gly131. Editor’s Choice

*Pillemer, S., Ayers, E., & Holtzer, R. (2018). Gender stratified analyses reveal longitudinal associations between social support and cognitive decline in men. Aging and Mental Health, 17, 1-7. doi: 10.1080/13607863.2018.1495178.

*Holtzer, R., Izzetoglu, M., Chen, M., & Wang, C. (2018). Distinct fNIRS-derived HbO2 trajectories during the course and over repeated walking trials under single and dual-task conditions: implications for within session learning and prefrontal cortex efficiency in older adults. Journal of Gerontology Medical Sciences, 74(7), 1076-1083. doi: 10.1093/gerona/gly181.

Holtzer, R., George, C. J., Izzetoglu, M., & Wang, C. (2018). The effect of diabetes on prefrontal cortex activation patterns during active walking in older adults. Brain and Cognition, 125:14- 22. doi: 10.1016/j.bandc.2018.03.002.

*Sleight, C., & Holtzer, R. (2018). Differential associations of functional and cognitive health outcomes with pre-frailty and frailty states in community-dwelling older adults. Journal of Health Psychology, 25(8), 1057-1063. doi: 10.1177/1359105317745964.

*Chen, M., Pillemer, S., England, S., Izzetoglu, M., Mahoney, J. R., & Holtzer, R. (2017). Neural correlates of obstacle negotiation in older adults: an fNIRS study. Gait Posture, 58:130-13. doi: 10.1016/j.gaitpost.2017.07.043.

*Chen, M., Blumen, H. M., Izzetoglu, M., & Holtzer, R. (2017). Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI. Journal of Neuroimaging, 27(5), 453-460. doi: 10.1111/jon.12432.

Gubbi, S., Schwartz, E., Crandall, J., Verghese, J., Holtzer, R., Atzmon, G., Braunstein, R., Barzilai, N., & Milman, S. (2017). Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. American Journal of Cardiology,15;120(12):2170-2175. doi: 10.1016/j.amjcard.2017.08.040.

Chaparro, G., Balto, J. M., Sandroff, B. M., Holtzer, R., Izzetoglu, M., Motl, R. W., & Hernandez, M. E. (2017). Frontal brain activation changes due to dual-tasking underpartial body weight support conditions in older adults with multiple sclerosis. Journal of NeuroEngineering & Rehabilitation, 14(1):65. doi: 10.1186/s12984-017-0280-8.

Ayers, E., Shapiro, M., Holtzer, R., Barzilai, N., Milman, S., & Verghese, J. (2017). Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults. Journal of Clinical Psychiatry, May;78(5):529-536. doi: 10.4088/JCP.15m10113.

*Holtzer, R., Schoen, C., Demetriou, E., Mahoney, J., Wang, C. & Verghese, J. (2017). Stress and gender effects on prefrontal cortex oxygenation levels assessed during single and dual-task walking conditions. The European Journal of Neuroscience, 45(5):660-670. doi: 10.1111/ejn.13518.

Perrochon, A., Holtzer, R., Laidet, M., Armand, S., Assal, F., Lalive, P. H., & Allali, G. (2017). Postural control is associated with cognition and fear of falling in patients with multiple sclerosis. Journal of Neural Transmission (Vienna), 124(4):495- 500. doi: 10.1007/s00702-016-1668-5.

Verghese, J., Wang, C., Ayers, E., Izzetoglu, M., & Holtzer, R. (2017). Brain activation in high-functioning older adults and falls Prospective cohort study. Neurology, 1,88(2), 191-197. doi: 10.1212/WNL.0000000000003421.

*Demetriou, E., & Holtzer, R. (2017). Mild Cognitive Impairments Moderate the Effect of Time on Verbal Fluency Performance. Journal of the International Neuropsychological Society, 23(1), 44-55. doi: 10.1017/S1355617716000825.

Allali, G., Ayers, E. I., Holtzer, R., & Verghese, J. (2017). The role of postural instability/gait difficulty and fear of falling in predicting falls in non-demented older adults. Archives of gerontology and geriatrics, 69, 15-20. doi: 10.1016/j.archger.2016.09.008.

*Shuman-Paretsky, M., Zemon, V., Foley, F., & Holtzer, R. (2017). Development and Validation of the State-Trait Inventory of Cognitive Fatigue in Community-Dwelling Older Adult. Archives of Physical Medicine & Rehabilitation, Apr;98(4):766-773. doi: 10.1016/j.apmr.2016.07.024.

*Holtzer, R., Yuan, J., Verghese, J., Mahoney, J. R., Izzetoglu, M., & Wang, C. (2017). Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion. Journal of Gerontology Medical Sciences, Mar 1;72(3):417-423. doi: 10.1093/gerona/glw167.

*Schoen, C. & Holtzer, R. (2016). Differential relationships of somatic and cognitive anxiety with measures of processing speed in older adults. Aging, Neuropsychology and Cognition, 7, 1-15. doi: 10.1080/13825585.2016.1226247.

Perice, L., Barzilai, N., Verghese, J., Weiss, E. F., Holtzer, R., Cohen, P., & Milman, S. (2016). Lower circulating insulin- like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging, 8:2414-24. doi: 10.18632/aging.101063.

Hernandez, M. E., Holtzer, R., Chaparro, G., Jean, K., Balto, J. M., Sandroff, B. M., Holtzer, R., & Motl, R. W. (2016). Brain activation changes during locomotion in middle-aged to older adults with multiple sclerosis. Journal of the Neurological Sciences, 370, 277-283. doi: 10.1016/j.jns.2016.10.002.

Verghese, J., Ayers, E., Mahoney, J. R., Ambrose, A., Wang, C., & Holtzer, R. (2016). Cognitive remediation to enhance mobility in older adults: the CREM study. Neurodegenerative disease Management, 6(6), 457-466. DOI: 10.2217/nmt-2016-0034

Djukic, A., Holtzer, R., Shinnar, S., Muzumdar, H., Rose, S., Mowrey, W., ... & Moshe, S. L. (2016). Pharmacological Treatment of Rett Syndrome with Glatiramer Acetate (Copaxone). Pediatric Neurology, 61, 51-57. doi: 10.1016/j.pediatrneurol.2016.05.010.

*Tow, A., Holtzer, R., Wang, C., Sharan, A., Kim, S. J., Gladstein, A., ... & Verghese, J. (2016). Cognitive Reserve and Postoperative Delirium in Older Adults. Journal of the American Geriatrics Society, 64(6), 1341-1346. doi: 10.1111/jgs.14130.

*Gromisch, E. S., Zemon, V., Holtzer, R., Chiaravalloti, N. D., DeLuca, J., Beier, M., ... & Foley, F. W. (2016). Assessing the criterion validity of four highly abbreviated measures from the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS). The Clinical Neuropsychologist, 1-18. doi: 10.1080/13854046.2016.1189597.

*Pillemer, S., Holtzer, R., & Blumen, H. M. (2017). Functional connectivity associated with social networks in older adults: A resting-state fMRI study. Social Neuroscience, 12(3), 242-252. doi:10.1080/17470919.2016.1176599

Verghese, J., Wang, C., Allali, G., Holtzer, R., & Ayers, E. (2016). Modifiable Risk Factors for New-Onset Slow Gait in Older Adults. Journal of the American Medical Directors Association, 17(5), 421-425. doi:10.1016/j.jamda.2016.01.017

Holtzer, R., Verghese, J., Allali, G., Izzetoglu, M., Wang, C., & Mahoney, J. R. (2016). Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis. Brain Topography, 29(2), 334-343. doi:10.1007/s10548-015-0465-z

*Pillemer, S. C., & Holtzer, R. (2016). The differential relationships of dimensions of perceived social support with cognitive function among older adults. Aging & Mental Health, 20(7), 727-735. doi:10.1080/13607863.2015.1033683

Mahoney, J. R., Holtzer, R., Izzetoglu, M., Zemon, V., Verghese, J., & Allali, G. (2016). The role of prefrontal cortex during postural control in Parkinsonian syndromes a functional near-infrared spectroscopy study. Brain Research, 1633, 126-138. doi:10.1016/j.brainres.2015.10.053

*Holtzer, R., Mahoney, J. R., Izzetoglu, M., Wang, C., England, S., & Verghese, J. (2015). Online fronto-cortical control of simple and attention-demanding locomotion in humans. NeuroImage, 112, 152-159. doi:10.1016/j.neuroimage.2015.03.002

*Mahoney, J. R., Dumas, K., & Holtzer, R. (2015). Visual-Somatosensory Integration is Linked to Physical Activity Level in Older Adults. Multisensory Research, 28(1-2), 11-29.

*LeMonda, B. C., Mahoney, J. R., Verghese, J., & Holtzer, R. (2015). The Association between High Neuroticism-Low Extraversion and Dual-Task Performance during Walking While Talking in Non-demented Older Adults. Journal of the International Neuropsychological Society, 21(7), 519-530. doi:10.1017/s1355617715000570

*Yuan, J., Blumen, H. M., Verghese, J., & Holtzer, R. (2015). Functional connectivity associated with gait velocity during walking and walking-while-talking in aging: a resting state fMRI study. Human Brain Mapping, 36(4), 1484-1493. doi:10.1002/hbm.22717

*Scharaga, E. A., & Holtzer, R. (2015). Preliminary Findings of the Brief Everyday Activities Measurement (BEAM) in Older Adults. Journal of Nutrition, Health, & Aging, 19(9), 929-934. doi:10.1007/s12603-015-0545-5

Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., . . .Holtzer, R., … Zhang, L. I. (2015). At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer’s & Dementia, 11(1), 70-98. doi:10.1016/j.jalz.2014.04.514

*England, S. E., Verghese, J., Mahoney, J. R., Trantzas, C., & Holtzer, R. (2015). Three-level rating of turns while walking. Gait and Posture, 41(1), 300-303. doi:10.1016/j.gaitpost.2014.09.010

Verghese, J., Annweiler, C., Ayers, E., Barzilai, N., Beauchet, O., Bennett, D. A., . . . Holtzer, R., … Wang, C. (2014). Motoric cognitive risk syndrome: multicountry prevalence and dementia risk. Neurology, 83(8), 718-726. doi:10.1212/wnl.0000000000000717

Verghese, J., Ayers, E., Barzilai, N., Bennett, D. A., Buchman, A. S., Holtzer, R., . . . Wang, C. (2014). Motoric cognitive risk syndrome: Multicenter incidence study. Neurology, 83(24), 2278-2284. doi:10.1212/wnl.0000000000001084

Mahoney, J. R., Verghese, J., Holtzer, R., & Allali, G. (2014). The evolution of mild parkinsonian signs in aging. Journal of Neurology, 261(10), 1922-1928. doi:10.1007/s00415-014-7442-4

Mahoney, J. R., Holtzer, R., & Verghese, J. (2014). Visual-somatosensory integration and balance: evidence for psychophysical integrative differences in aging. Multisensory Research, 27(1), 17-42.

Lee, S. W., Verghese, J., Holtzer, R., Mahoney, J. R., & Oh-Park, M. (2014). Trunk sway during walking among older adults: norms and correlation with gait velocity. Gait & Posture, 40(4), 676-681. doi:10.1016/j.gaitpost.2014.07.023

*Li, C., Verghese, J., & Holtzer, R. (2014). A comparison of two walking while talking paradigms in aging. Gait & Posture, 40(3), 415-419. doi:10.1016/j.gaitpost.2014.05.062

Mahoney, J. R., Holtzer, R., & Verghese, J. (2014). Visual-somatosensory integration and balance: evidence for psychophysical integrative differences in aging. Multisensory Research, 27(1), 17-42.

*Shuman-Paretsky, M. J., Belser-Ehrlich, J., & Holtzer, R. (2014). Psychometric properties of the Brief Fatigue Inventory in community-dwelling older adults. Archives of Physical Medicine and Rehabilitation, 95(8), 1533-1539. doi:10.1016/j.apmr.2014.03.026

*Holtzer, R., Epstein, N., Mahoney, J. R., Izzetoglu, M., & Blumen, H. M. (2014). Neuroimaging of mobility in aging: a targeted review. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(11), 1375-1388. doi:10.1093/gerona/glu052

Learmonth, Y. C., Sandroff, B. M., Pilutti, L. A., Klaren, R. E., Ensari, I., Riskin, B. J., Holtzer, R., & Motl, R. W. (2014). Cognitive motor interference during walking in multiple sclerosis using an alternate-letter alphabet task. Archives of Physical Medicine Rehabilitation, 95(8), 1498-1503. doi:10.1016/j.apmr.2014.03.007

Blumen, H. M., Holtzer, R., Brown, L. L., Gazes, Y., & Verghese, J. (2014). Behavioral and neural correlates of imagined walking and walking-while-talking in the elderly. Human Brain Mapping, 35(8), 4090-4104. doi:10.1002/hbm.22461

Ayers, E. I., Tow, A. C., Holtzer, R., & Verghese, J. (2014). Walking while talking and falls in aging. Gerontology, 60(2), 108-113. doi:10.1159/000355119

*Mahoney, J. R., Wang, C., Dumas, K., & Holtzer, R. (2014). Visual-somatosensory integration in aging: does stimulus location really matter? Visual Neuroscience, 31(3), 275-283. doi:10.1017/s0952523814000078

Holtzer, R., Mahoney, J., & Verghese, J. (2014). Intraindividual variability in executive functions but not speed of processing or conflict resolution predicts performance differences in gait speed in older adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(8), 980-986. doi:10.1093/gerona/glt180

Verghese, J., Wang, C., Lipton, R. B., & Holtzer, R. (2013). Motoric cognitive risk syndrome and the risk of dementia. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(4), 412-418. doi:10.1093/gerona/gls191

*Holtzer, R., Foley, F., D'Orio, V., Spat, J., Shuman, M., & Wang, C. (2013). Learning and cognitive fatigue trajectories in multiple sclerosis defined using a burst measurement design. Multiple Sclerosis Journal, 19(11), 1518-1525. doi:10.1177/1352458513477922

Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., Raghavan, P., & Verghese, J. (2013). Motor dual-task effect on gait and task of upper limbs in older adults under specific task prioritization: pilot study. Aging Clinical and Experimental Research, 25(1), 99-106. doi:10.1007/s40520-013-0014-0

Verghese, J., Holtzer, R., Wang, C., Katz, M. J., Barzilai, N., & Lipton, R. B. (2013). Role of APOE genotype in gait decline and disability in aging. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 68(11), 1395-1401. doi:10.1093/gerona/glt115

Holtzer, R., Wang, C., & Verghese, J. (2014). Performance variance on walking while talking tasks: theory, findings, and clinical implications. Age, 36(1), 373-381. doi:10.1007/s11357-013-9570-7

*D'Orio, V. L., Foley, F. W., Armentano, F., Picone, M. A., Kim, S., & Holtzer, R. (2012). Cognitive and motor functioning in patients with multiple sclerosis: neuropsychological predictors of walking speed and falls. Journal of Neurological Sciences, 316(1-2), 42-46. doi:10.1016/j.jns.2012.02.003

*Mahoney, J. R., Verghese, J., Dumas, K., Wang, C., & Holtzer, R. (2012). The effect of multisensory cues on attention in aging. Brain Research, 1472, 63-73. doi:10.1016/j.brainres.2012.07.014

*LeMonda, B. C., Holtzer, R., & Goldman, S. (2012). Relationship between executive functions and motor stereotypies in children with Autistic Disorder. Research in Autism Spectrum Disorders,6(3), 1099-1106. doi 10.1016/j.rasd.2012.03.001

Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2012). High-sensitivity C-reactive protein and mobility disability in older adults. Age Ageing, 41(4), 541-545. doi:10.1093/ageing/afs038

Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2012). Mobility stress test approach to predicting frailty, disability, and mortality in high-functioning older adults. Journal of the American Geriatrics Society, 60(10), 1901-1905. doi:10.1111/j.1532-5415.2012.04145.x

Holtzer, R., Zweig, R. A., & Siegel, L. J. (2012). Learning From The Past and Planning For The Future: The Challenges Of And Solutions For Integrating Aging Into Doctoral Psychology Training. Training and Education in Professional Psychology, 6(3), 142-150. doi:10.1037/a0029365

Holtzer, R., Wang, C., Lipton, R., & Verghese, J. (2012). The protective effects of executive functions and episodic memory on gait speed decline in aging defined in the context of cognitive reserve. Journal of the American Geriatrics Society, 60(11), 2093-2098. doi:10.1111/j.1532-5415.2012.04193.x

Brandler, T. C., Wang, C., Oh-Park, M., Holtzer, R., & Verghese, J. (2012). Depressive symptoms and gait dysfunction in the elderly. The American Journal of Geriatrics Psychiatry, 20(5), 425-432. doi:10.1097/JGP.0b013e31821181c6

Holtzer, R., Wang, C., & Verghese, J. (2012). The relationship between attention and gait in aging: facts and fallacies. Motor Control, 16(1), 64-80. doi:10.1123/mcj.16.1.64

Brandler, T. C., Oh-Park, M., Wang, C., Holtzer, R., & Verghese, J. (2012). Walking while talking: investigation of alternate forms. Gait & Posture, 35(1), 164-166. doi:10.1016/j.gaitpost.2011.08.003

*Holtzer, R., Shuman, M., Mahoney, J. R., Lipton, R., & Verghese, J. (2011). Cognitive fatigue defined in the context of attention networks. Aging Neuropsychology and Cognition, 18(1), 108-128. doi:10.1080/13825585.2010.517826

Benedict, R. H., Holtzer, R., Motl, R. W., Foley, F. W., Kaur, S., Hojnacki, D., & Weinstock-Guttman, B. (2011). Upper and lower extremity motor function and cognitive impairment in multiple sclerosis. Journal of the International Neuropsychological Society, 17(4), 643-653. doi:10.1017/s1355617711000403

Verghese, J., Wang, C., & Holtzer, R. (2011). Relationship of clinic-based gait speed measurement to limitations in community-based activities in older adults. Archives of Physical Medicine & Rehabilitation, 92(5), 844-846. doi:10.1016/j.apmr.2010.12.030

Oh-Park, M., Xue, X., Holtzer, R., & Verghese, J. (2011). Transient versus persistent fear of falling in community-dwelling older adults: incidence and risk factors. Journal of the American Geriatrics Society, 59(7), 1225-1231. doi:10.1111/j.1532-5415.2011.03475.x

Holtzer, R., Mahoney, J. R., Izzetoglu, M., Izzetoglu, K., Onaral, B., & Verghese, J. (2011). fNIRS study of walking and walking while talking in young and old individuals. Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 66(8), 879-887. doi:10.1093/gerona/glr068

Mahoney, J. R., Li, P. C., Oh-Park, M., Verghese, J., & Holtzer, R. (2011). Multisensory integration across the senses in young and old adults. Brain Research, 1426, 43-53. doi:10.1016/j.brainres.2011.09.017

Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., & Verghese, J. (2011). Effect of treadmill training on specific gait parameters in older adults with frailty: Case series. Journal of Geriatric Physical Therapy, 34(4), 184-188. doi:10.1519/JPT.0b013e3182193165

Verghese, J., Holtzer, R., Oh-Park, M., Derby, C. A., Lipton, R. B., & Wang, C. (2011). Inflammatory markers and gait speed decline in older adults. Journal of Gerontology Series A: Biological Sciences & Medical Sciences, 66(10), 1083-1089. doi:10.1093/gerona/glr099

Holtzer, R., Ozelius, L., Xue, X., Wang, T., Lipton, R. B., & Verghese, J. (2010). Differential effects of COMT on gait and executive control in aging. Neurobiology of Aging, 31(3), 523-531. doi:10.1016/j.neurobiolaging.2008.05.011

Rolita, L., Holtzer, R., Wang, C., Lipton, R. B., Derby, C. A., & Verghese, J. (2010). Homocysteine and mobility in older adults. Journal of the American Geriatric Society, 58(3), 545-550. doi:10.1111/j.1532-5415.2010.02718.x

*Vederman, A. C., Holtzer, R., Zimmerman, M. E., Devinsky, O., & Barr, W. B. (2010). Ictal mnemestic aura and verbal memory function. Epilepsy & Behavior, 17(4), 474-477. doi:10.1016/j.yebeh.2010.01.018

Verghese, J., & Holtzer, R. (2010). Walking the walk while talking: cognitive therapy for mobility in dementia? Neurology, 74(24), 1938-1939. doi:10.1212/WNL.0b013e3181e3d97d

Oh-Park, M., Holtzer, R., Xue, X., & Verghese, J. (2010). Conventional and robust quantitative gait norms in community-dwelling older adults. Journal of the American Geriatrics Society, 58(8), 1512-1518. doi:10.1111/j.1532-5415.2010.02962.x

*Mahoney, J. R., Verghese, J., Goldin, Y., Lipton, R., & Holtzer, R. (2010). Alerting, orienting, and executive attention in older adults. Journal of the International Neuropsychological Society, 16(5), 877-889. doi:10.1017/s1355617710000767

Verghese, J., Mahoney, J., Ambrose, A. F., Wang, C., & Holtzer, R. (2010). Effect of cognitive remediation on gait in sedentary seniors. Journal of Gerontology A: Biological Science Medical Science, 65(12), 1338-1343. doi:10.1093/gerona/glq127

Holtzer, R., & Foley, F. (2009). The relationship between subjective reports of fatigue and executive control in multiple sclerosis. Journal of the Neurological Sciences, 281(1-2), 46-50. doi:10.1016/j.jns.2009.02.360

Holtzer, R., Rakitin, B. C., Steffener, J., Flynn, J., Kumar, A., & Stern, Y. (2009). Age effects on load-dependent brain activations in working memory for novel material. Brain Research, 1249, 148-161. doi:10.1016/j.brainres.2008.10.009

*Holtzer, R., Goldin, Y., & Donovick, P. J. (2009). Extending the administration time of the letter fluency test increases sensitivity to cognitive status in aging. Experimental Aging Research, 35(3), 317-326. doi:10.1080/03610730902922119

Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2009). Quantitative gait markers and incident fall risk in older adults. Journal of Gerontology A: Biological Science Medical Science, 64(8), 896-901. doi:10.1093/gerona/glp033

Sanders, A. E., Holtzer, R., Lipton, R. B., Hall, C., & Verghese, J. (2008). Egocentric and exocentric navigation skills in older adults. Journal of Gerontology A: Biological Science and Medical Science, 63(12), 1356-1363. doi:10.1093/gerona/63.12.1356

*Holtzer, R., Goldin, Y., Zimmerman, M., Katz, M., Buschke, H., & Lipton, R. B. (2008). Robust norms for selected neuropsychological tests in older adults. Archives of Clinical Neuropsychology, 23(5), 531-541. doi:10.1016/j.acn.2008.05.004

Holtzer, R., Verghese, J., Wang, C., Hall, C. B., & Lipton, R. B. (2008). Within-person across-neuropsychological test variability and incident dementia. Journal of the American Medical Association (JAMA), 300(7), 823-830. doi:10.1001/jama.300.7.823

Verghese, J., Robbins, M., Holtzer, R., Zimmerman, M., Wang, C., Xue, X., & Lipton, R. B. (2008). Gait dysfunction in mild cognitive impairment syndromes. Journal of the American Geriatric Society, 56(7), 1244-1251. doi:10.1111/j.1532-5415.2008.01758.x

Verghese, J., Wang, C., Xue, X., & Holtzer, R. (2008). Self-reported difficulty in climbing up or down stairs in nondisabled elderly. Archives of Physical Medicine, 89(1), 100-104. doi:10.1016/j.apmr.2007.08.129

Stern, Y., Zarahn, E., Habeck, C., Holtzer, R., Rakitin, B. C., Kumar, A., . . . Brown, T. (2008). A common neural network for cognitive reserve in verbal and object working memory in young but not old. Cerebral Cortex, 18(4), 959-967. doi:10.1093/cercor/bhm134

Donovick, P.J., Portocarrero, J.S., Holtzer, R., Yee, R.S. (2008). Incarceration, Stress, & Dementia, Public Safety Canada: The Proceedings of the 2007 North American Correctional & Criminal Justice Psychology Conference 2008-02, 129-133.

Verghese, J., Kuslansky, G., Holtzer, R., Katz, M., Pahor, M., Buschke, H. (2007). Walking while talking: Effect of task prioritization. Archives of Physical Medicine. 88(1):50-53. doi: 10.1016/j.apmr.2006.10.007

Verghese, J., Wang, C., Lipton, R. B., Holtzer, R., Xue, X. (2007). Quantitative gait dysfunction and risk of cognitive decline and dementia. Journal of Neurology, Neurosurgery & Psychiatry, 78(9), 929-935. doi:10.1136/jnnp.2006.106914

*Holtzer, R., Friedman, R., Lipton, R. B., Katz, M., Xue, X., & Verghese, J. (2007). The relationship between specific cognitive functions and falls in the elderly. Neuropsychology, 21(5): 540-548. doi: 10.1037/0894-4105.21.5.540

Holtzer, R., Verghese, J., Xue, X., & Lipton, R. B. (2006). Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology, 20(2), 215-223. doi: 10.1037/0894-4105.20.2.215

Holtzer, R., Wegesin, D. J., Albert, S. M., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern Y. (2006). The relation of Concurrent Alpha Synuclein pathology to clinical outcome in autopsy-proven Alzheimer disease. Archives of Neurology, 63, 226-230. doi: 10.1001/archneur.63.2.226

Holtzer, R., Scrameas, N., Wegesin, D. J., Albert, S. M., Albert, M., Brandt, J., Hadgieorgiou, G. M., Dubois, B., & Stern, Y. (2005). Depressive symptoms in Alzheimer Disease: natural course and temporal relation to function and cognitive status. Journal of the American Geriatric Society, 53, 2083- 2089. doi: 10.1111/j.1532-5415.2005.00535.x.

Holtzer, R., Rakitin, C. B., & Stern, Y. (2005). Predicting age related dual-task effects with individual differences on neuropsychological tests. Neuropsychology, 19(1), 18-27.

Holtzer, R., Wegesin, D.J., & Stern Y. (2004). The Prevalence, Course and Risk Factors of psychopathological Features in Alzheimer Disease. Practice in Alzheimer's Disease and Cognitive Decline, 9, 165-173.

Holtzer, R., Rakitin, C. B., & Stern, Y. (2004). Age-related differences in executive control of working memory. Memory & Cognition, 32(8), 1333-1345.

Holtzer, R. (2004). Review: Behavioral Neurology and Neuropsychology, 2nd edition. Archives of Neurology, 61, 1469.

Holtzer, R., Burright, R. G., & Donovick, P. J. (2004). The Sensitivity of Dual-task Performance to Cognitive Status in Aging. Journal of the International Neuropsychological Society, 10(2), 230- 238.

Holtzer, R., Tang, M-X., Devanand, D. P., Albert, S. M., Wegesin, D. J., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern, Y. (2003). Psychopathologic Features in Alzheimer’s Disease: Course and Relation to Cognitive Status. Journal of the American Geriatric Society, 51, 953-960.

Holtzer, R., Wegesin, D. J., Albert, S. M., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern, Y. (2003). The Rate of Cognitive Decline and Risk of Reaching Clinical Milestones in Alzheimer’s Disease. Archives of Neurology, 60, 1137-1142.

Holtzer, R., Burright, R. G., & Donovick PJ. (2001). Mattis Dementia Rating Scale: Performance in the Very Elderly. Clinical Gerontologist, 24(3/4), 107-114.

Holtzer, R., Burright, R. G., Lynn, S. J., & Donovick, P. J. (2000). Behavioral differences between psychiatric patients with confirmed versus non-confirmed traumatic brain injuries. Brain Injury, 14(11), 959-973.

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