NEUROPSYCHOLOGY COGNITION AND MOBILITY LAB

*Denotes current or former students as co-authors

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Holtzer, R., Choi, J., Motl, R. W., Foley, F. W., Wagshul, M. E., Hernandez, M. E., & Izzetoglu, M. (2024). Brain control of dual-task walking can be improved in aging and neurological disease. Geroscience. https://doi.org/10.1007/s11357-023-01054-3

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*Cote, S. E., Wagshul, M., Foley, F. W., Picone, M. A., Lipton, M., Lee, J. S., & Holtzer, R. (2024). Frontal-striatal tract integrity and depression in older adults with and without multiple sclerosis. Neurol Sci. https://doi.org/10.1007/s10072-024-07316-y  

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Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M. E., & Holtzer, R. (2023). Initial validation of the university of Alabama Birmingham study of aging life-space assessment in older adults with multiple sclerosis. Mult Scler Relat Disord, 82, 105354. https://doi.org/10.1016/j.msard.2023.105354 

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Ma, D., Izzetoglu, M., Holtzer, R., & Jiao, X. (2023). Deep Learning Based Walking Tasks Classification in Older Adults Using fNIRS. IEEE Trans Neural Syst Rehabil Eng, 31, 3437-3447. https://doi.org/10.1109/tnsre.2023.3306365 

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*Brundage, K., Holtzer, R. (2023). Presence and Persistence of Perceived Subjective Cognitive Complaints and Incident Mild Cognitive Impairments Among Community-Residing Older Adults. The American Journal Geriatric Psychiatry. doi: 10.1016/j.jagp.2023.07.001. Online ahead of print.

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*Cote S.E., Wagshul, M.E., Foley, F.W., Lipton, M.L., Holtzer, R. (2023). Caudate Volume and Symptoms of Apathy in Older Adults with Multiple Sclerosis. Multiple Sclerosis Journal. doi: 10.1177/13524585231188096. Online ahead of print.

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*Cohen, H.R., Holtzer, R. (2023). The Association Between Perceived Social Support and Cognition in Older Adults with and without Multiple Sclerosis. Multiple Sclerosis and Related Disorders. doi: 10.1016/j.msard.2023.104913. Online ahead of print.

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*Ross, D., Wagshul, M.E.,Izzetoglu, M., Holtzer, R. (2023). Cortical Thickness Moderates Intraindividual Variability in Prefrontal Cortex Activation Patterns of Older Adults During Walking. Journal of the International Neuropsychological Society. doi: 10.1017/S1355617723000371. Online ahead of print.

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*Jacobs, S., Izzetoglu, M., Holtzer, R. (2023).   The Impact of Music Making on Neural Efficiency & Dual-Task Walking Performance in Healthy Older Adults.  Aging Neuropsychology and Cognition. Mar 31:1-19. doi: 10.1080/13825585.2023.2195615. Online ahead of print

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*Wasserman, J., Holtzer, R. (2023).   Depressive Symptoms Are Associated With Decline Over Time in Verbal Fluency Performance in Female But Not Male Community-Residing Older Adults. Experimental Aging Research. Mar 29:1-16. doi: 10.1080/0361073X.2023.2195295. Online ahead of print

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Holtzer, R., Choi, J., Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M., & Wagshul, M. E. (2023). Individual reserve in aging and neurological disease. Journal of neurology, 1–13. Advance online publication. https://doi.org/10.1007/s00415-023-11656-8

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*Pace, B., Holtzer, R., & Wagshul, M. E. (2023). Gray matter volume and within-task verbal fluency performance among older adults. Brain and cognition, 166, 105960. https://doi.org/10.1016/j.bandc.2023.105960

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*O'Brien, C., & Holtzer, R. (2023). Physical reserve: construct development and predictive utility. Aging clinical and experimental research, 10.1007/s40520-023-02371-5. Advance online publication. https://doi.org/10.1007/s40520-023-02371-5

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Holtzer, R., Feldman, J. M., Jariwala, S. P., & Izzetoglu, M. (2023). Asthma history influences gait performance and associated prefrontal cortex activation patterns in older adults. Aging clinical and experimental research, 35(2), 407–411. https://doi.org/10.1007/s40520-022-02306-6

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Wagshul, M.,, Foley, F.W., Chaudhary, K., Lipton, M.L., Robert Motl, R., Izzetoglu, M., Hernandez, M.E., Picone, M.A., & Holtzer, R., (2023).   Differential Associations of Mobility with Fronto-Striatal Integrity and Lesion Load in Older Adults with and without Multiple Sclerosis.  Neurorehabilitation and Neural Repair. Apr;37(4):205-217. doi: 10.1177/15459683231164787.

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Holtzer, R., Zhu, X., Rosso, A. L., & Rosano, C. (2022). Cognitive reserve and risk of mobility impairment in older adults. Journal of the American Geriatrics Society, 10.1111/jgs.17979. Advance online publication. https://doi.org/10.1111/jgs.17979

 

Krasovsky, T., Madi, R., Fruchter, E., Jahjah, E., & Holtzer, R. (2022). Prefrontal Cortex Brain Activation During Texting and Walking: A Functional Near-Infrared Spectroscopy Feasibility Study. Motor control, 1–10. Advance online publication. https://doi.org/10.1123/mc.2022-0009

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*Guharajan, D., & Holtzer, R. (2022). Association of Affect and Performance in Dual-Task Walking in Non-demented Older Adults. Journal of aging and health, 8982643221087836. Advance online publication. https://doi.org/10.1177/08982643221087836

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Holtzer R. (2022). Volitional control of walking in aging. Aging, 14(6), 2440–2441. https://doi.org/10.18632/aging.203986

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Maidan, I., Hacham, R., Galperin, I., Giladi, N., Holtzer, R., Hausdorff, J. M., & Mirelman, A. (2021). Neural Variability in the Prefrontal Cortex as a Reflection of Neural Flexibility and Stability in Patients With Parkinson Disease. Neurology. Advance online publication. https://doi.org/10.1212/WNL.0000000000013217

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Holtzer, R., *Ross, D., O'Brien, C., Izzetoglu, M., & Wagshul, M. E. (2021). Cognitive Reserve Moderates the Efficiency of Prefrontal Cortex Activation Patterns of Gait in Older Adults. The Journals of Gerontology: Series A. Advance online publication. https://doi.org/10.1093/gerona/glab288

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Verghese, J., Mahoney, J. R., Ayers, E., Ambrose, A., Wang, C., & Holtzer, R. (2021). Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial. Lancet Healthy Longev, 2(9), e571–e579. https://doi.org/10.1016/s2666-7568(21)00173-2

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*Ross, D., Wagshul, M. E., Izzetoglu, M., & Holtzer, R. (2021). Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions. GeroScience, 43(4), 1959-1974. https://doi.org/10.1007/s11357-021-00379-1

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*O'Brien, C., & Holtzer, R. (2021). Cognitive Reserve Moderates Associations Between Walking Performance Under Single and Dual-Task Conditions and Incident Mobility Impairment in Older Adults. The Journals of Gerontology: Series A, 76(10), e314-e320. https://doi.org/10.1093/gerona/glab178

 

*Kraut, R., & Holtzer, R. (2021). Recurrent but not single report of fear of falling predicts cognitive decline in community-residing older adults. Aging & mental health, 1–7. Advance online publication. https://doi.org/10.1080/13607863.2021.1916878

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Bishnoi, A., Holtzer, R., & Hernandez, M. E. (2021). Brain Activation Changes While Walking in Adults with and without Neurological Disease: Systematic Review and Meta-Analysis of Functional Near-Infrared Spectroscopy Studies. Brain sciences, 11(3), 291. https://doi.org/10.3390/brainsci11030291

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*Pakray, H., Seng, E., Izzetoglu, M., & Holtzer, R. (2021). The Effects of Perceived Pain in the Past Month on Prefrontal Cortex Activation Patterns Assessed During Cognitive and Motor Performances in Older Adults. Pain medicine, 22(2), 303–314. https://doi.org/10.1093/pm/pnaa404

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*Holtzer, R., Ross, D., & Izzetoglu, M. (2020). Intraindividual variability in neural activity in the prefrontal cortex during active walking in older adults. Psychology and aging, 35(8), 1201–1214. https://doi.org/10.1037/pag0000583

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Menant, J. C., Maidan, I., Alcock, L., Al-Yahya, E., Cerasa, A., Clark, D. J., de Bruin, E. D., Fraser, S., Gramigna, V., Hamacher, D., Herold, F., Holtzer, R., Izzetoglu, M., Lim, S., Pantall, A., Pelicioni, P., Peters, S., Rosso, A. L., St George, R., Stuart, S., … Mirelman, A. (2020). A consensus guide to using functional near-infrared spectroscopy in posture and gait research. Gait & posture, 82, 254–265. https://doi.org/10.1016/j.gaitpost.2020.09.012

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*Jacobs, S., Mercuri, G., & Holtzer, R. (2021). Assessing within-task verbal fluency performance: the utility of individual time intervals in predicting incident mild cognitive impairment. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 28(5), 733-747. https://doi.org/10.1080/13825585.2020.1817306

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*Mercuri, G., & Holtzer, R. (2021). Engagement in Cognitively Stimulating Activities Mediates the Relationship between Openness and Attention/Executive Functions, but Not Memory in Older Adults. Archives of Clinical Neuropsychology. 36(4), 485-497. https://doi.org/10.1093/arclin/acaa066

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Holtzer, R., & Izzetoglu, M. (2020). Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults. Brain sciences, 10(7), 415. https://doi.org/10.3390/brainsci10070415

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Izzetoglu, M., & Holtzer, R. (2020). Effects of Processing Methods on fNIRS Signals Assessed During Active Walking Tasks in Older Adults. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 28(3), 699–709. https://doi.org/10.1109/TNSRE.2020.2970407

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*Lee, J., & Holtzer, R. (2021). Independent associations of apathy and depressive symptoms with perceived social support in healthy older adults. Aging & mental health, 25(10), 1796-1802. https://doi.org/10.1080/13607863.2020.1768217

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*Holtzer, R., Jacobs, S., & Demetriou, E. (2020). Intraindividual variability in verbal fluency performance is moderated by and predictive of mild cognitive impairments. Neuropsychology, 34(1), 31–42. https://doi.org/10.1037/neu0000576

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Udina, C., Avtzi, S., Durduran, T., Holtzer, R., Rosso, A. L., Castellano-Tejedor, C., Perez, L. M., Soto-Bagaria, L., & Inzitari, M. (2020). Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review. Frontiers in aging neuroscience, 11, 367. https://doi.org/10.3389/fnagi.2019.00367

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Zhang, W. B., Aleksic, S., Gao, T., Weiss, E. F., Demetriou, E., Verghese, J., Holtzer, R., Barzilai, N., & Milman, S. (2020). Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults. Cells, 9(6), 1368. https://doi.org/10.3390/cells9061368

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*Jacobs, S. & Holtzer, R. (2021). Predicting Change in Perceived Social Support in Late Life: The Role of Personality and Gender. Aging Ment Health. 25(1), 107-117. doi: 10.1080/13607863.2019.1671317.

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Hoffnung, G., Portnoy, J.G., Altaras, C., Zemon, V., Holtzer, R., Picone, M.A., Foley, F.W. (2019). Motivation in Multiple Sclerosis Cognitive Fatigue: An Experimental Approach. J Clin Exp Neuropsychol. doi: 10.1080/13803395.2019.1626350.

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Hernandez, M. E., O'Donnell, E., Chaparro, G., Holtzer, R., Izzetoglu, M., Sandroff, B. M., & Motl, R. W. (2019). Brain Activation Changes During Balance- and Attention-Demanding Tasks in Middle- and Older-Aged Adults With Multiple Sclerosis. Motor Control, 15, 1-20. doi: 10.1123/mc.2018-0044.

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*Holtzer, R., Kraut, R., & Ye, K. (2019). The effect of fear of falling on prefrontal cortex activation and efficiency. GeroScience, 41:1, 89-100. doi: 10.1007/s11357-019-00056-4.

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*Wagshul, M. E., Lucas, M., Izzetoglu, M., Ye, K., & Holtzer, R. (2019). Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults. NeuroImage, 1:189, 745-754. doi: 10.1016/j.neuroimage.2019.01.045.

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George, C.J., Verghese, J., Izzetoglu, M., Wang, C., & Holtzer, R. (2019). The effect of polypharmacy on prefrontal cortex activation during single and dual-task walking in community dwelling older adults. Pharmacological Research, 139, 113-119. doi: 10.1016/j.phrs.2018.11.007.

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*Lucas, M., Wagshul, M. E., Izzetoglu, M., & Holtzer, R. (2019). Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults. Journal of Gerontology Biological Sciences, 74:4, 435-441. doi: 10.1093/gerona/gly131. Editor’s Choice

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*Pillemer, S., Ayers, E., & Holtzer, R. (2018). Gender stratified analyses reveal longitudinal associations between social support and cognitive decline in men. Aging and Mental Health, 17, 1-7. doi: 10.1080/13607863.2018.1495178.

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*Holtzer, R., Izzetoglu, M., Chen, M., & Wang, C. (2018). Distinct fNIRS-derived HbO2 trajectories during the course and over repeated walking trials under single and dual-task conditions: implications for within session learning and prefrontal cortex efficiency in older adults. Journal of Gerontology Medical Sciences, 74(7), 1076-1083. doi: 10.1093/gerona/gly181.

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Holtzer, R., George, C. J., Izzetoglu, M., & Wang, C. (2018). The effect of diabetes on prefrontal cortex activation patterns during active walking in older adults. Brain and Cognition, 125:14- 22. doi: 10.1016/j.bandc.2018.03.002.

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*Sleight, C., & Holtzer, R. (2018). Differential associations of functional and cognitive health outcomes with pre-frailty and frailty states in community-dwelling older adults. Journal of Health Psychology, 25(8), 1057-1063. doi: 10.1177/1359105317745964.

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*Chen, M., Pillemer, S., England, S., Izzetoglu, M., Mahoney, J. R., & Holtzer, R. (2017). Neural correlates of obstacle negotiation in older adults: an fNIRS study. Gait Posture, 58:130-13. doi: 10.1016/j.gaitpost.2017.07.043.

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*Chen, M., Blumen, H. M., Izzetoglu, M., & Holtzer, R. (2017). Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI. Journal of Neuroimaging, 27(5), 453-460. doi: 10.1111/jon.12432.

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Gubbi, S., Schwartz, E., Crandall, J., Verghese, J., Holtzer, R., Atzmon, G., Braunstein, R., Barzilai, N., & Milman, S. (2017). Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. American Journal of Cardiology,15;120(12):2170-2175. doi: 10.1016/j.amjcard.2017.08.040.

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Chaparro, G., Balto, J. M., Sandroff, B. M., Holtzer, R., Izzetoglu, M., Motl, R. W., & Hernandez, M. E. (2017). Frontal brain activation changes due to dual-tasking underpartial body weight support conditions in older adults with multiple sclerosis. Journal of NeuroEngineering & Rehabilitation, 14(1):65. doi: 10.1186/s12984-017-0280-8.

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Ayers, E., Shapiro, M., Holtzer, R., Barzilai, N., Milman, S., & Verghese, J. (2017). Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults. Journal of Clinical Psychiatry, May;78(5):529-536. doi: 10.4088/JCP.15m10113. 

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*Holtzer, R., Schoen, C., Demetriou, E., Mahoney, J., Wang, C. & Verghese, J. (2017). Stress and gender effects on prefrontal cortex oxygenation levels assessed during single and dual-task walking conditions. The European Journal of Neuroscience, 45(5):660-670. doi: 10.1111/ejn.13518.

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Perrochon, A., Holtzer, R., Laidet, M., Armand, S., Assal, F., Lalive, P. H., & Allali, G. (2017). Postural control is associated with cognition and fear of falling in patients with multiple sclerosis. Journal of Neural Transmission (Vienna), 124(4):495- 500. doi: 10.1007/s00702-016-1668-5.

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Verghese, J., Wang, C., Ayers, E., Izzetoglu, M., & Holtzer, R. (2017). Brain activation in high-functioning older adults and falls Prospective cohort study. Neurology, 1,88(2), 191-197. doi: 10.1212/WNL.0000000000003421.

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*Demetriou, E., & Holtzer, R. (2017). Mild Cognitive Impairments Moderate the Effect of Time on Verbal Fluency Performance. Journal of the International Neuropsychological Society,  23(1), 44-55. doi: 10.1017/S1355617716000825. 

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Allali, G., Ayers, E. I., Holtzer,  R., & Verghese, J. (2017). The role of postural instability/gait difficulty and fear of falling in predicting falls in non-demented older adults. Archives of gerontology and geriatrics, 69, 15-20. doi: 10.1016/j.archger.2016.09.008.

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*Shuman-Paretsky, M., Zemon, V., Foley, F., & Holtzer, R. (2017). Development and Validation of the State-Trait Inventory of Cognitive Fatigue in Community-Dwelling Older Adult. Archives of Physical Medicine & Rehabilitation, Apr;98(4):766-773. doi: 10.1016/j.apmr.2016.07.024.

 

*Holtzer, R., Yuan, J., Verghese, J., Mahoney, J. R., Izzetoglu, M., & Wang, C. (2017). Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion. Journal of Gerontology Medical Sciences, Mar 1;72(3):417-423. doi: 10.1093/gerona/glw167.

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*Schoen, C. & Holtzer, R. (2016). Differential relationships of somatic and cognitive anxiety with measures of processing speed in older adults. Aging, Neuropsychology and Cognition, 7, 1-15. doi: 10.1080/13825585.2016.1226247.

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Perice, L., Barzilai, N., Verghese, J., Weiss, E. F., Holtzer, R., Cohen, P., & Milman, S. (2016). Lower circulating insulin- like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging, 8:2414-24. doi: 10.18632/aging.101063.

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Hernandez, M. E., Holtzer, R., Chaparro, G., Jean, K., Balto, J. M., Sandroff, B. M., Holtzer, R., & Motl, R. W. (2016). Brain activation changes during locomotion in middle-aged to older adults with multiple sclerosis. Journal of the Neurological Sciences, 370, 277-283. doi: 10.1016/j.jns.2016.10.002.

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Verghese, J., Ayers, E., Mahoney, J. R., Ambrose, A., Wang, C., & Holtzer, R. (2016). Cognitive remediation to enhance mobility in older adults: the CREM study. Neurodegenerative disease Management, 6(6), 457-466. DOI: 10.2217/nmt-2016-0034

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Djukic, A., Holtzer, R., Shinnar, S., Muzumdar, H., Rose, S., Mowrey, W., ... & Moshe, S. L. (2016). Pharmacological Treatment of Rett Syndrome with Glatiramer Acetate (Copaxone). Pediatric Neurology, 61, 51-57. doi: 10.1016/j.pediatrneurol.2016.05.010.

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*Tow, A., Holtzer, R., Wang, C., Sharan, A., Kim, S. J., Gladstein, A., ... & Verghese, J. (2016). Cognitive Reserve and Postoperative Delirium in Older Adults. Journal of the American Geriatrics Society, 64(6), 1341-1346. doi: 10.1111/jgs.14130.

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*Gromisch, E. S., Zemon, V., Holtzer, R., Chiaravalloti, N. D., DeLuca, J., Beier, M., ... & Foley, F. W. (2016). Assessing the criterion validity of four highly abbreviated measures from the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS). The Clinical Neuropsychologist, 1-18. doi: 10.1080/13854046.2016.1189597. 

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*Pillemer, S., Holtzer, R., & Blumen, H. M. (2017). Functional connectivity associated with social networks in older adults: A resting-state fMRI study. Social Neuroscience, 12(3), 242-252. doi:10.1080/17470919.2016.1176599

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Verghese, J., Wang, C., Allali, G., Holtzer, R., & Ayers, E. (2016). Modifiable Risk Factors for New-Onset Slow Gait in Older Adults. Journal of the American Medical Directors Association, 17(5), 421-425. doi:10.1016/j.jamda.2016.01.017

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Holtzer, R., Verghese, J., Allali, G., Izzetoglu, M., Wang, C., & Mahoney, J. R. (2016). Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis. Brain Topography, 29(2), 334-343. doi:10.1007/s10548-015-0465-z

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*Pillemer, S. C., & Holtzer, R. (2016). The differential relationships of dimensions of perceived social support with cognitive function among older adults. Aging & Mental Health, 20(7), 727-735. doi:10.1080/13607863.2015.1033683

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Mahoney, J. R., Holtzer, R., Izzetoglu, M., Zemon, V., Verghese, J., & Allali, G. (2016). The role of prefrontal cortex during postural control in Parkinsonian syndromes a functional near-infrared spectroscopy study. Brain Research, 1633, 126-138. doi:10.1016/j.brainres.2015.10.053

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*Holtzer, R., Mahoney, J. R., Izzetoglu, M., Wang, C., England, S., & Verghese, J. (2015). Online fronto-cortical control of simple and attention-demanding locomotion in humans. NeuroImage, 112, 152-159. doi:10.1016/j.neuroimage.2015.03.002

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*Mahoney, J. R., Dumas, K., & Holtzer, R. (2015). Visual-Somatosensory Integration is Linked to Physical Activity Level in Older Adults. Multisensory Research, 28(1-2), 11-29.

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*LeMonda, B. C., Mahoney, J. R., Verghese, J., & Holtzer, R. (2015). The Association between High Neuroticism-Low Extraversion and Dual-Task Performance during Walking While Talking in Non-demented Older Adults. Journal of the International Neuropsychological Society, 21(7), 519-530. doi:10.1017/s1355617715000570

 

*Yuan, J., Blumen, H. M., Verghese, J., & Holtzer, R. (2015). Functional connectivity associated with gait velocity during walking and walking-while-talking in aging: a resting state fMRI study. Human Brain Mapping, 36(4), 1484-1493. doi:10.1002/hbm.22717

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*Scharaga, E. A., & Holtzer, R. (2015). Preliminary Findings of the Brief Everyday Activities Measurement (BEAM) in Older Adults. Journal of Nutrition, Health, & Aging, 19(9), 929-934. doi:10.1007/s12603-015-0545-5

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Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., . . .Holtzer, R., … Zhang, L. I. (2015). At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer’s & Dementia, 11(1), 70-98. doi:10.1016/j.jalz.2014.04.514

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*England, S. E., Verghese, J., Mahoney, J. R., Trantzas, C., & Holtzer, R. (2015). Three-level rating of turns while walking. Gait and Posture, 41(1), 300-303. doi:10.1016/j.gaitpost.2014.09.010

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Verghese, J., Annweiler, C., Ayers, E., Barzilai, N., Beauchet, O., Bennett, D. A., . . . Holtzer, R., … Wang, C. (2014). Motoric cognitive risk syndrome: multicountry prevalence and dementia risk. Neurology, 83(8), 718-726. doi:10.1212/wnl.0000000000000717

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Verghese, J., Ayers, E., Barzilai, N., Bennett, D. A., Buchman, A. S., Holtzer, R., . . . Wang, C. (2014). Motoric cognitive risk syndrome: Multicenter incidence study. Neurology, 83(24), 2278-2284. doi:10.1212/wnl.0000000000001084

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Mahoney, J. R., Verghese, J., Holtzer, R., & Allali, G. (2014). The evolution of mild parkinsonian signs in aging. Journal of Neurology, 261(10), 1922-1928. doi:10.1007/s00415-014-7442-4

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Mahoney, J. R., Holtzer, R., & Verghese, J. (2014). Visual-somatosensory integration and balance: evidence for psychophysical integrative differences in aging. Multisensory Research, 27(1), 17-42. 

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Lee, S. W., Verghese, J., Holtzer, R., Mahoney, J. R., & Oh-Park, M. (2014). Trunk sway during walking among older adults: norms and correlation with gait velocity. Gait & Posture, 40(4), 676-681. doi:10.1016/j.gaitpost.2014.07.023

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*Li, C., Verghese, J., & Holtzer, R. (2014). A comparison of two walking while talking paradigms in aging. Gait & Posture, 40(3), 415-419. doi:10.1016/j.gaitpost.2014.05.062

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Mahoney, J. R., Holtzer, R., & Verghese, J. (2014). Visual-somatosensory integration and balance: evidence for psychophysical integrative differences in aging. Multisensory Research, 27(1), 17-42. 

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*Shuman-Paretsky, M. J., Belser-Ehrlich, J., & Holtzer, R. (2014). Psychometric properties of the Brief Fatigue Inventory in community-dwelling older adults. Archives of Physical Medicine and Rehabilitation, 95(8), 1533-1539. doi:10.1016/j.apmr.2014.03.026

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*Holtzer, R., Epstein, N., Mahoney, J. R., Izzetoglu, M., & Blumen, H. M. (2014). Neuroimaging of mobility in aging: a targeted review. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(11), 1375-1388. doi:10.1093/gerona/glu052

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Learmonth, Y. C., Sandroff, B. M., Pilutti, L. A., Klaren, R. E., Ensari, I., Riskin, B. J., Holtzer, R., & Motl, R. W. (2014). Cognitive motor interference during walking in multiple sclerosis using an alternate-letter alphabet task. Archives of Physical Medicine Rehabilitation, 95(8), 1498-1503. doi:10.1016/j.apmr.2014.03.007

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Blumen, H. M., Holtzer, R., Brown, L. L., Gazes, Y., & Verghese, J. (2014). Behavioral and neural correlates of imagined walking and walking-while-talking in the elderly. Human Brain Mapping, 35(8), 4090-4104. doi:10.1002/hbm.22461

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Ayers, E. I., Tow, A. C., Holtzer, R., & Verghese, J. (2014). Walking while talking and falls in aging. Gerontology, 60(2), 108-113. doi:10.1159/000355119

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*Mahoney, J. R., Wang, C., Dumas, K., & Holtzer, R. (2014). Visual-somatosensory integration in aging: does stimulus location really matter? Visual Neuroscience, 31(3), 275-283. doi:10.1017/s0952523814000078

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Holtzer, R., Mahoney, J., & Verghese, J. (2014). Intraindividual variability in executive functions but not speed of processing or conflict resolution predicts performance differences in gait speed in older adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(8), 980-986. doi:10.1093/gerona/glt180

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Verghese, J., Wang, C., Lipton, R. B., & Holtzer, R. (2013). Motoric cognitive risk syndrome and the risk of dementia. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(4), 412-418. doi:10.1093/gerona/gls191

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*Holtzer, R., Foley, F., D'Orio, V., Spat, J., Shuman, M., & Wang, C. (2013). Learning and cognitive fatigue trajectories in multiple sclerosis defined using a burst measurement design. Multiple Sclerosis Journal, 19(11), 1518-1525. doi:10.1177/1352458513477922

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Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., Raghavan, P., & Verghese, J. (2013). Motor dual-task effect on gait and task of upper limbs in older adults under specific task prioritization: pilot study. Aging Clinical and Experimental Research, 25(1), 99-106. doi:10.1007/s40520-013-0014-0

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Verghese, J., Holtzer, R., Wang, C., Katz, M. J., Barzilai, N., & Lipton, R. B. (2013). Role of APOE genotype in gait decline and disability in aging. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 68(11), 1395-1401. doi:10.1093/gerona/glt115

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Holtzer, R., Wang, C., & Verghese, J. (2014). Performance variance on walking while talking tasks: theory, findings, and clinical implications. Age, 36(1), 373-381. doi:10.1007/s11357-013-9570-7

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*D'Orio, V. L., Foley, F. W., Armentano, F., Picone, M. A., Kim, S., & Holtzer, R. (2012). Cognitive and motor functioning in patients with multiple sclerosis: neuropsychological predictors of walking speed and falls. Journal of Neurological Sciences, 316(1-2), 42-46. doi:10.1016/j.jns.2012.02.003

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*Mahoney, J. R., Verghese, J., Dumas, K., Wang, C., & Holtzer, R. (2012). The effect of multisensory cues on attention in aging. Brain Research, 1472, 63-73. doi:10.1016/j.brainres.2012.07.014

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*LeMonda, B. C., Holtzer, R., & Goldman, S. (2012). Relationship between executive functions and motor stereotypies in children with Autistic Disorder. Research in Autism Spectrum Disorders,6(3), 1099-1106. doi 10.1016/j.rasd.2012.03.001

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Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2012). High-sensitivity C-reactive protein and mobility disability in older adults. Age Ageing, 41(4), 541-545. doi:10.1093/ageing/afs038

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Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2012). Mobility stress test approach to predicting frailty, disability, and mortality in high-functioning older adults. Journal of the American Geriatrics Society, 60(10), 1901-1905. doi:10.1111/j.1532-5415.2012.04145.x

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Holtzer, R., Zweig, R. A., & Siegel, L. J. (2012). Learning From The Past and Planning For The Future: The Challenges Of And Solutions For Integrating Aging Into Doctoral Psychology Training. Training and Education in Professional Psychology, 6(3), 142-150. doi:10.1037/a0029365

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Holtzer, R., Wang, C., Lipton, R., & Verghese, J. (2012). The protective effects of executive functions and episodic memory on gait speed decline in aging defined in the context of cognitive reserve. Journal of the American Geriatrics Society, 60(11), 2093-2098. doi:10.1111/j.1532-5415.2012.04193.x

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Brandler, T. C., Wang, C., Oh-Park, M., Holtzer, R., & Verghese, J. (2012). Depressive symptoms and gait dysfunction in the elderly. The American Journal of Geriatrics Psychiatry, 20(5), 425-432. doi:10.1097/JGP.0b013e31821181c6

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Holtzer, R., Wang, C., & Verghese, J. (2012). The relationship between attention and gait in aging: facts and fallacies. Motor Control, 16(1), 64-80. doi:10.1123/mcj.16.1.64

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Brandler, T. C., Oh-Park, M., Wang, C., Holtzer, R., & Verghese, J. (2012). Walking while talking: investigation of alternate forms. Gait & Posture, 35(1), 164-166. doi:10.1016/j.gaitpost.2011.08.003

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Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., Raghavan, P., & Verghese, J. (2013). Motor dual-task effect on gait and task of upper limbs in older adults under specific task prioritization: pilot study. Aging Clinical and Experimental Research, 25(1), 99-106. doi:10.1007/s40520-013-0014-0

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*Holtzer, R., Shuman, M., Mahoney, J. R., Lipton, R., & Verghese, J. (2011). Cognitive fatigue defined in the context of attention networks. Aging Neuropsychology and Cognition, 18(1), 108-128. doi:10.1080/13825585.2010.517826

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Benedict, R. H., Holtzer, R., Motl, R. W., Foley, F. W., Kaur, S., Hojnacki, D., & Weinstock-Guttman, B. (2011). Upper and lower extremity motor function and cognitive impairment in multiple sclerosis. Journal of the International Neuropsychological Society, 17(4), 643-653. doi:10.1017/s1355617711000403

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Verghese, J., Wang, C., & Holtzer, R. (2011). Relationship of clinic-based gait speed measurement to limitations in community-based activities in older adults. Archives of Physical Medicine & Rehabilitation, 92(5), 844-846. doi:10.1016/j.apmr.2010.12.030

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Oh-Park, M., Xue, X., Holtzer, R., & Verghese, J. (2011). Transient versus persistent fear of falling in community-dwelling older adults: incidence and risk factors. Journal of the American Geriatrics Society, 59(7), 1225-1231. doi:10.1111/j.1532-5415.2011.03475.x

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Holtzer, R., Mahoney, J. R., Izzetoglu, M., Izzetoglu, K., Onaral, B., & Verghese, J. (2011). fNIRS study of walking and walking while talking in young and old individuals. Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 66(8), 879-887. doi:10.1093/gerona/glr068

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Mahoney, J. R., Li, P. C., Oh-Park, M., Verghese, J., & Holtzer, R. (2011). Multisensory integration across the senses in young and old adults. Brain Research, 1426, 43-53. doi:10.1016/j.brainres.2011.09.017

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Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., & Verghese, J. (2011). Effect of treadmill training on specific gait parameters in older adults with frailty: Case series. Journal of Geriatric Physical Therapy, 34(4), 184-188. doi:10.1519/JPT.0b013e3182193165

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Verghese, J., Holtzer, R., Oh-Park, M., Derby, C. A., Lipton, R. B., & Wang, C. (2011). Inflammatory markers and gait speed decline in older adults. Journal of Gerontology Series A: Biological Sciences & Medical Sciences, 66(10), 1083-1089. doi:10.1093/gerona/glr099

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Holtzer, R., Ozelius, L., Xue, X., Wang, T., Lipton, R. B., & Verghese, J. (2010). Differential effects of COMT on gait and executive control in aging. Neurobiology of Aging, 31(3), 523-531. doi:10.1016/j.neurobiolaging.2008.05.011

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Rolita, L., Holtzer, R., Wang, C., Lipton, R. B., Derby, C. A., & Verghese, J. (2010). Homocysteine and mobility in older adults. Journal of the American Geriatric Society, 58(3), 545-550. doi:10.1111/j.1532-5415.2010.02718.x

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*Vederman, A. C., Holtzer, R., Zimmerman, M. E., Devinsky, O., & Barr, W. B. (2010). Ictal mnemestic aura and verbal memory function. Epilepsy & Behavior, 17(4), 474-477. doi:10.1016/j.yebeh.2010.01.018

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Verghese, J., & Holtzer, R. (2010). Walking the walk while talking: cognitive therapy for mobility in dementia? Neurology, 74(24), 1938-1939. doi:10.1212/WNL.0b013e3181e3d97d

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Oh-Park, M., Holtzer, R., Xue, X., & Verghese, J. (2010). Conventional and robust quantitative gait norms in community-dwelling older adults. Journal of the American Geriatrics Society, 58(8), 1512-1518. doi:10.1111/j.1532-5415.2010.02962.x

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*Mahoney, J. R., Verghese, J., Goldin, Y., Lipton, R., & Holtzer, R. (2010). Alerting, orienting, and executive attention in older adults. Journal of the International Neuropsychological Society, 16(5), 877-889. doi:10.1017/s1355617710000767

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Verghese, J., Mahoney, J., Ambrose, A. F., Wang, C., & Holtzer, R. (2010). Effect of cognitive remediation on gait in sedentary seniors. Journal of Gerontology A: Biological Science Medical Science, 65(12), 1338-1343. doi:10.1093/gerona/glq127

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Holtzer, R., & Foley, F. (2009). The relationship between subjective reports of fatigue and executive control in multiple sclerosis. Journal of the Neurological Sciences, 281(1-2), 46-50. doi:10.1016/j.jns.2009.02.360

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Holtzer, R., Rakitin, B. C., Steffener, J., Flynn, J., Kumar, A., & Stern, Y. (2009). Age effects on load-dependent brain activations in working memory for novel material. Brain Research, 1249, 148-161. doi:10.1016/j.brainres.2008.10.009

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*Holtzer, R., Goldin, Y., & Donovick, P. J. (2009). Extending the administration time of the letter fluency test increases sensitivity to cognitive status in aging. Experimental Aging Research, 35(3), 317-326. doi:10.1080/03610730902922119

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Verghese, J., Holtzer, R., Lipton, R. B., & Wang, C. (2009). Quantitative gait markers and incident fall risk in older adults. Journal of Gerontology A: Biological Science Medical Science, 64(8), 896-901. doi:10.1093/gerona/glp033

 

Sanders, A. E., Holtzer, R., Lipton, R. B., Hall, C., & Verghese, J. (2008). Egocentric and exocentric navigation skills in older adults. Journal of Gerontology A: Biological Science and Medical Science, 63(12), 1356-1363. doi:10.1093/gerona/63.12.1356

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*Holtzer, R., Goldin, Y., Zimmerman, M., Katz, M., Buschke, H., & Lipton, R. B. (2008). Robust norms for selected neuropsychological tests in older adults. Archives of Clinical Neuropsychology, 23(5), 531-541. doi:10.1016/j.acn.2008.05.004

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Holtzer, R., Verghese, J., Wang, C., Hall, C. B., & Lipton, R. B. (2008). Within-person across-neuropsychological test variability and incident dementia. Journal of the American Medical Association (JAMA), 300(7), 823-830. doi:10.1001/jama.300.7.823

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Verghese, J., Robbins, M., Holtzer, R., Zimmerman, M., Wang, C., Xue, X., & Lipton, R. B. (2008). Gait dysfunction in mild cognitive impairment syndromes. Journal of the American Geriatric Society, 56(7), 1244-1251. doi:10.1111/j.1532-5415.2008.01758.x

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Verghese, J., Wang, C., Xue, X., & Holtzer, R. (2008). Self-reported difficulty in climbing up or down stairs in nondisabled elderly. Archives of Physical Medicine, 89(1), 100-104. doi:10.1016/j.apmr.2007.08.129

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Stern, Y., Zarahn, E., Habeck, C., Holtzer, R., Rakitin, B. C., Kumar, A., . . . Brown, T. (2008). A common neural network for cognitive reserve in verbal and object working memory in young but not old. Cerebral Cortex, 18(4), 959-967. doi:10.1093/cercor/bhm134

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Donovick, P.J., Portocarrero, J.S., Holtzer, R., Yee, R.S. (2008). Incarceration, Stress, & Dementia, Public Safety Canada: The Proceedings of the 2007 North American Correctional & Criminal Justice Psychology Conference 2008-02, 129-133.

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Verghese, J., Kuslansky, G., Holtzer, R., Katz, M., Pahor, M., Buschke, H. (2007). Walking while talking: Effect of task prioritization. Archives of Physical Medicine. 88(1):50-53. doi: 10.1016/j.apmr.2006.10.007

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Verghese, J., Wang, C., Lipton, R. B., Holtzer, R., Xue, X. (2007). Quantitative gait dysfunction and risk of cognitive decline and dementia. Journal of Neurology, Neurosurgery & Psychiatry, 78(9), 929-935. doi:10.1136/jnnp.2006.106914

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*Holtzer, R., Friedman, R., Lipton, R. B., Katz, M., Xue, X., & Verghese, J. (2007). The relationship between specific cognitive functions and falls in the elderly. Neuropsychology, 21(5): 540-548. doi: 10.1037/0894-4105.21.5.540

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Holtzer, R., Verghese, J., Xue, X., & Lipton, R. B. (2006). Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology, 20(2), 215-223. doi: 10.1037/0894-4105.20.2.215

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Holtzer, R., Wegesin, D. J., Albert, S. M., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern Y. (2006). The relation of Concurrent Alpha Synuclein pathology to clinical outcome in autopsy-proven Alzheimer disease. Archives of Neurology, 63, 226-230. doi: 10.1001/archneur.63.2.226

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Holtzer, R., Scrameas, N., Wegesin, D. J., Albert, S. M., Albert, M., Brandt, J., Hadgieorgiou, G. M., Dubois, B., & Stern, Y. (2005). Depressive symptoms in Alzheimer Disease: natural course and temporal relation to function and cognitive status. Journal of the American Geriatric Society, 53, 2083- 2089. doi: 10.1111/j.1532-5415.2005.00535.x.

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Holtzer, R., Rakitin, C. B., & Stern, Y. (2005). Predicting age related dual-task effects with individual differences on neuropsychological tests. Neuropsychology, 19(1), 18-27.

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Holtzer, R., Wegesin, D.J., & Stern Y. (2004). The Prevalence, Course and Risk Factors of psychopathological Features in Alzheimer Disease. Practice in Alzheimer's Disease and Cognitive Decline, 9, 165-173.

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Holtzer, R., Rakitin, C. B., & Stern, Y. (2004). Age-related differences in executive control of working memory. Memory & Cognition, 32(8), 1333-1345.

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Holtzer, R. (2004). Review: Behavioral Neurology and Neuropsychology, 2nd edition. Archives of Neurology, 61, 1469.

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Holtzer, R., Burright, R. G., & Donovick, P. J. (2004). The Sensitivity of Dual-task Performance to Cognitive Status in Aging. Journal of the International Neuropsychological Society, 10(2), 230- 238.

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Holtzer, R., Tang, M-X., Devanand, D. P., Albert, S. M., Wegesin, D. J., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern, Y. (2003). Psychopathologic Features in Alzheimer’s Disease: Course and Relation to Cognitive Status. Journal of the American Geriatric Society, 51, 953-960.

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Holtzer, R., Wegesin, D. J., Albert, S. M., Marder, K., Bell, K., Albert, M., Brandt, J., & Stern, Y. (2003). The Rate of Cognitive Decline and Risk of Reaching Clinical Milestones in Alzheimer’s Disease. Archives of Neurology, 60, 1137-1142.

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Holtzer, R., Burright, R. G., & Donovick PJ. (2001). Mattis Dementia Rating Scale: Performance in the Very Elderly. Clinical Gerontologist, 24(3/4), 107-114.

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Holtzer, R., Burright, R. G., Lynn, S. J., & Donovick, P. J. (2000). Behavioral differences between psychiatric patients with confirmed versus non-confirmed traumatic brain injuries. Brain Injury, 14(11), 959-973.